FACTS ABOUT KETAMINE ASSISTED PSYCHOTHERAPY REVEALED

Metabolism Ketamine is metabolized by using N-dealkylation on the active metabolite norketamine mostly by CYP2B6 and CYP3A4 and to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation of the cyclohexone ring to variety hydroxynorketamine compounds by using CYP-dependent pathways, which are conjugated with glucuronic acid and su